Description

2-Bromo-6-(Chloromethyl)Pyridine is a versatile and highly functionalized pyridine derivative, serving as a critical bifunctional building block in advanced organic synthesis. Its dual reactive sites—the bromine and chloromethyl groups—enable sequential and selective transformations, making it invaluable for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing sophisticated nitrogen-containing ligands used in transition metal catalysis.
• Material Science: Employed in the creation of functional polymers and organic electronic materials due to its aromatic pyridine core and reactive handles.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: The chloromethyl group is highly reactive towards various nucleophiles, facilitating the introduction of diverse functional groups.

Basic Information

Product Name	2-Bromo-6-(Chloromethyl)Pyridine
CAS No.	727356-19-6
Molecular Formula	C6H5BrClN
Molecular Weight	206.47 g/mol
Synonyms	6-(Chloromethyl)-2-bromopyridine; 2-Bromo-6-chloromethylpyridine; (6-Bromopyridin-2-yl)methyl chloride; 2-Bromo-6-(chloromethyl)pyridine; Pyridine, 2-bromo-6-(chloromethyl)-; 727356-19-6
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-(Chloromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates and ISO standards for industrial chemicals, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.