Description

n-Succinimidyl 7-Maleimidoheptanote is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a thiol-reactive maleimide group. This compound is essential for creating stable, site-specific conjugates between proteins, peptides, and other biomolecules, enabling advanced research and development. It is a critical tool for scientists and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay formulation.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Protein-Protein/Peptide Conjugation: For creating defined, covalent linkages between different proteins or peptides while preserving functional activity.
• Enzyme and Protein Immobilization: Used to attach enzymes or other proteins to solid supports, nanoparticles, or sensor surfaces via thiol or amine groups.
• Fluorescent Probe and Diagnostic Reagent Labeling: Enables the site-specific attachment of fluorophores, haptens, or other reporter molecules to antibodies and proteins.
• Polymer and Biomaterial Functionalization: Introduces reactive maleimide groups onto polymers or materials for subsequent bioconjugation applications.
• Stable Conjugate Formation for Research: Facilitates the production of stable, well-characterized conjugates for structural biology, immunology, and cell biology studies.

Basic Information

Product Name	n-Succinimidyl 7-Maleimidoheptanote
CAS No.	724721-93-1
Molecular Formula	C17H22N2O7
Molecular Weight	366.37 g/mol
Synonyms	7-Maleimidoheptanoic Acid N-Hydroxysuccinimide Ester; SMCC (Succinimidyl 4-(N-Maleimidomethyl)cyclohexane-1-carboxylate) analog; NHS-PEG7-Maleimide; Maleimide-PEG7-NHS Ester; N-(7-Maleimidobutanoyloxy)succinimide; Succinimidyl 7-maleimidoheptanoate; 1-[7-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)heptanoyloxy]-2,5-pyrrolidinedione; Heterobifunctional Crosslinker (NHS/Maleimide).
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 7-Maleimidoheptanote is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive bioconjugation applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and functional group activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.