Description

3-Pyridinol,6-Amino-2,3,4,5-Tetrahydro-4-Methyl-,Acetate(Ester),(3S,4R)-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its role as a critical chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific stereochemistry is essential for biological activity. Pharmaceutical R&D and manufacturing organizations need this material for developing and producing next-generation therapeutics, particularly in neurological and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease targets.
• Asymmetric Synthesis Building Block: Utilized in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for API manufacturing under GMP conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Probe Development: Acts as a precursor for creating labeled compounds or probes used in mechanistic and pharmacological studies.

Basic Information

Product Name	3-Pyridinol,6-Amino-2,3,4,5-Tetrahydro-4-Methyl-,Acetate(Ester),(3S,4R)-(9Ci)
CAS No.	724418-70-6
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	(3S,4R)-6-Amino-4-methyl-2,3,4,5-tetrahydro-3-pyridinol acetate; (3S,4R)-4-Methyl-6-amino-1,2,3,4,5,6-hexahydro-3-pyridinyl acetate; 6-Amino-4-methyl-2,3,4,5-tetrahydro-3-pyridinyl acetate (3S,4R)-; 6-Amino-4-methyl-1,2,3,4,5,6-hexahydro-3-pyridinol acetate (stereo); Acetic acid (3S,4R)-6-amino-4-methyl-2,3,4,5-tetrahydro-3-pyridinyl ester; (3S,4R)-6-Amino-4-methyl-1,2,3,4,5,6-hexahydro-3-pyridyl acetate; Stereoisomer of 6-Amino-4-methyl-2,3,4,5-tetrahydro-3-pyridinol acetate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. Production can be aligned with GMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (3S,4R)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.