Description

3,3,4,4,4-Pentafluoro-2-Hydroxy-2-Phenylbutyric Acid Methyl Ester is a high-value fluorinated organic building block, distinguished by its unique combination of a pentafluoroalkyl group and a chiral hydroxy ester functionality. This compound is critical for introducing fluorine atoms into target molecules, a key strategy for modulating their physicochemical and biological properties. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for introducing fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms contribute to improved activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Acts as a precursor for fluorinated components in electronic display materials, influencing dielectric anisotropy and stability.
• Advanced Polymer Modification: Employed to incorporate fluorine into polymer side chains, imparting properties like oil repellency, chemical resistance, and low surface energy.
• Organic Synthesis & Catalysis: Functions as a versatile reagent in asymmetric synthesis and catalysis development, leveraging its chiral center and reactive ester group.
• Fluorinated Surfactant & Coating Precursor: Used to develop specialty surfactants and high-performance coatings with unique wetting and leveling characteristics.

Basic Information

Product Name	3,3,4,4,4-Pentafluoro-2-Hydroxy-2-Phenylbutyric Acid Methyl Ester
CAS No.	723294-72-2
Molecular Formula	C11H9F5O3
Molecular Weight	284.18 g/mol
Synonyms	Methyl 3,3,4,4,4-pentafluoro-2-hydroxy-2-phenylbutanoate; 2-Hydroxy-2-phenyl-3,3,4,4,4-pentafluorobutanoic Acid Methyl Ester; Methyl α-Hydroxy-α-phenyl-β,β,β,γ,γ-pentafluorobutyrate; Pentafluorohydroxy Phenyl Butyric Acid Methyl Ester; PFHPB Methyl Ester; CAS 723294-72-2
EINECS	Contact for details

Quality Control

Our production of 3,3,4,4,4-Pentafluoro-2-Hydroxy-2-Phenylbutyric Acid Methyl Ester adheres to stringent quality management protocols. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP and ISO standards for research and commercial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability, although the product is stable at controlled room temperature for shorter periods. Keep away from strong alkalis and incompatible materials. The container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.