Description

(R)-3''-Hydroxy Pravastatin Sodium Salt is a key chiral intermediate and metabolite of the widely used cholesterol-lowering drug, Pravastatin. Its significance lies in its role in advanced pharmaceutical research, particularly for studying metabolic pathways and developing novel statin-based therapies. This high-purity compound is essential for pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers engaged in the synthesis of next-generation HMG-CoA reductase inhibitors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the pharmacokinetics and metabolic profile of Pravastatin.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a chiral building block in the synthesis of Pravastatin and its structural analogs.
• Biochemical Assays: Employed as a substrate or inhibitor in enzymatic assays targeting HMG-CoA reductase activity.
• Impurity Profiling: Used to identify, quantify, and qualify related substances in Pravastatin drug substance and finished dosage forms.

Basic Information

Product Name	(R)-3''-Hydroxy Pravastatin Sodium Salt
CAS No.	722504-46-3
Molecular Formula	C₂₃H₃₅NaO₈
Molecular Weight	462.52 g/mol
Synonyms	(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-Hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid Sodium Salt; Pravastatin 3''-Sulfate Sodium Salt (referring to a common metabolic pathway); Pravastatin Metabolite Sodium Salt; 3''-Hydroxy Pravastatin Na; Sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoate
EINECS	Contact for details

Quality Control

Our (R)-3''-Hydroxy Pravastatin Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity, to ensure it meets the stringent requirements for pharmaceutical research and reference standard applications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.