Description

(R)-Benzyl 2-((tert-Butoxycarbonyl)Amino)-5-(Dimethylamino)-5-Oxopentanoate is a high-purity, chiral amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a protected, enantiomerically pure intermediate for constructing complex peptide and peptidomimetic structures. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and therapeutic peptides.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs and protease inhibitors.
• Peptidomimetic Research: Building block for creating non-natural peptide analogs with enhanced metabolic stability and bioavailability.
• API Development: Used in the research and scale-up production of new chemical entities (NCEs) and target molecules.
• Bioconjugation: Serves as a linker or spacer molecule in the design of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological pathways and enzyme function.
• Asymmetric Synthesis: A valuable starting material for catalytic asymmetric transformations to introduce complex chiral centers.

Basic Information

Product Name	(R)-Benzyl 2-((tert-Butoxycarbonyl)Amino)-5-(Dimethylamino)-5-Oxopentanoate
CAS No.	721927-49-7
Molecular Formula	C19H28N2O5
Molecular Weight	364.44 g/mol
Synonyms	Boc-D-Glu(OBzl)-N(Me)2; (R)-Benzyl 2-((Boc)amino)-5-(dimethylamino)-5-oxopentanoate; (R)-Benzyl 2-((tert-butoxycarbonyl)amino)-5-(dimethylamino)-5-oxopentanoate; N-Boc-N'-dimethyl-L-glutamic acid α-benzyl ester; Boc-D-Glutamic acid α-benzyl ester N,N-dimethylamide; Nα-Boc-Nδ-dimethyl-L-glutamine benzyl ester; (2R)-2-{[(tert-Butoxy)carbonyl]amino}-5-(dimethylamino)-5-oxopentanoic acid benzyl ester
EINECS	Contact for details

Quality Control

Our production of (R)-Benzyl 2-((tert-Butoxycarbonyl)Amino)-5-(Dimethylamino)-5-Oxopentanoate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. All materials are fully characterized by spectroscopic and chromatographic methods. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.