Description

2-[4-(Aminomethyl)Phenoxy]Acetic Acid tert-Butyl Ester is a versatile and high-value protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its bifunctional structure, featuring both a protected carboxylic acid group and a reactive aminomethyl moiety, which enables precise and efficient coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and complex specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug molecules, especially those requiring a phenoxyacetic acid backbone with a pendant amine functionality.
• Peptidomimetic Chemistry: Used to incorporate non-natural amino acid structures into peptide chains to enhance stability, bioavailability, or biological activity.
• Linker Molecule in Bioconjugation: The reactive amine group allows for attachment to other molecules, making it useful in creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides or plant growth regulators with specific phenoxy-based activity.
• Material Science Research: Employed in the creation of novel polymers or functionalized surfaces where controlled amine presentation is required.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring a specific, protected bifunctional aromatic building block.

Basic Information

Product Name	2-[4-(Aminomethyl)Phenoxy]Acetic Acid tert-Butyl Ester
CAS No.	720720-14-9
Molecular Formula	C14H21NO3
Molecular Weight	251.32 g/mol
Synonyms	tert-Butyl 2-[4-(aminomethyl)phenoxy]acetate; 4-(Aminomethyl)phenoxyacetic Acid tert-Butyl Ester; 2-(4-(Aminomethyl)phenoxy)acetic Acid 1,1-Dimethylethyl Ester; 2-(4-Aminomethylphenoxy)acetic Acid tert-Butyl Ester; Acetic Acid, 2-[4-(aminomethyl)phenoxy]-, 1,1-Dimethylethyl Ester; BOC-Aminomethyl-Phenoxy-Acetic Acid (common abbreviation context); t-Butyl 4-(Aminomethyl)phenoxyacetate
EINECS	Contact for details

Quality Control

Every batch of 2-[4-(Aminomethyl)Phenoxy]Acetic Acid tert-Butyl Ester is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.