Description

Sodium:(3R,5R)-3,5-Dihydroxy-7-[(1S,2S)-6-Hydroxy-2-Methyl-1,2-Dihydronaphthalen-1-Yl]Heptanoate is a high-purity, synthetically derived sodium salt of a complex dihydroxy heptanoic acid derivative. This compound is a critical pharmaceutical intermediate, valued for its defined stereochemistry and role in the synthesis of advanced active pharmaceutical ingredients (APIs). It is essential for manufacturers in the pharmaceutical and fine chemical sectors requiring precise chiral building blocks for research and production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly in cardiovascular and metabolic therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor or a direct component in the development of novel APIs, leveraging its specific (3R,5R) and (1S,2S) stereocenters.
• Biochemical Research: Used as a reference standard or a substrate in enzymatic studies and metabolic pathway research due to its hydroxy-functionalized structure.
• Process Chemistry & Scale-Up: Employed in process optimization and pilot-scale manufacturing for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized in stereoselective synthesis to construct molecules with high enantiomeric purity for advanced material science.

Basic Information

Product Name	Sodium:(3R,5R)-3,5-Dihydroxy-7-[(1S,2S)-6-Hydroxy-2-Methyl-1,2-Dihydronaphthalen-1-Yl]Heptanoate
CAS No.	720666-74-0
Molecular Formula	C18H23NaO5
Molecular Weight	342.36 g/mol
Synonyms	Sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S)-6-hydroxy-2-methyl-1,2-dihydronaphthalen-1-yl]heptanoate; (3R,5R)-3,5-Dihydroxy-7-[(1S,2S)-6-hydroxy-2-methyl-1,2-dihydronaphthalen-1-yl]heptanoic Acid Sodium Salt; Sodium Rosuvastatin Intermediate; Sodium Salt of Dihydroxy Heptanoic Acid Naphthalene Derivative; ZD4522 Sodium Salt Intermediate; CRESTOR® Related Compound Sodium Salt; (3R,5R,1S,2S)-Dihydroxy Heptanoate Sodium Salt
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality management systems. Every batch is subjected to comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, stereochemical purity, and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development and commercial projects requiring material manufactured under GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccated environment after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.