Description

1-n-Cbz-3-Aminopiperidine is a high-purity, protected piperidine derivative serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile, nitrogen-containing scaffold for constructing complex molecular architectures, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Peptidomimetic Chemistry: Used to introduce constrained piperidine motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Library Synthesis: Employed in parallel and combinatorial chemistry for generating diverse compound libraries for high-throughput screening.
• Agrochemical Research: Utilized as a building block in the development of novel herbicides, fungicides, and insecticides.
• Academic Research: A valuable reagent for methodological studies in organic chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	1-n-Cbz-3-Aminopiperidine
CAS No.	711002-74-3
Molecular Formula	C13H18N2O2
Molecular Weight	234.30 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-aminopiperidine; 3-Amino-1-Cbz-piperidine; 1-Carbobenzoxy-3-aminopiperidine; N-Cbz-3-Aminopiperidine; 3-Amino-1-(phenylmethoxy)carbonylpiperidine; 1-(Benzyloxycarbonyl)piperidin-3-amine; Piperidine, 3-amino-1-[(phenylmethoxy)carbonyl]-; Z-3-Aminopiperidine
EINECS	Contact for details

Quality Control

Our 1-n-Cbz-3-Aminopiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support our clients' regulatory needs and can supply material that meets the stringent requirements for cGMP starting material applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.