Description

Carbamic Acid, [(2R,3S)-2-Methyl-4-Oxo-3-Oxetanyl]-, 1,1-Dimethylethyl Ester is a high-purity, chiral oxetane derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical, protected intermediate for constructing complex bioactive molecules, particularly in the development of novel protease inhibitors and other targeted therapeutics. Its defined stereochemistry and reactive functional groups make it an essential building block for research and process chemists in the pharmaceutical and fine chemical industries seeking to introduce the oxetane motif, known for improving metabolic stability and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer agents.
• Protease Inhibitor Synthesis: Used in the construction of complex molecular scaffolds targeting proteolytic enzymes, such as HCV NS3/4A protease inhibitors.
• Medicinal Chemistry & Drug Discovery: Employed as a versatile building block for structure-activity relationship (SAR) studies and lead optimization programs.
• Stereoselective Synthesis: Utilized in asymmetric synthesis to introduce the (2R,3S)-configured oxetane ring system with high enantiomeric purity.
• Fine Chemical Production: Serves as a precursor for other specialized, high-value chiral compounds used in agrochemical and material science research.

Basic Information

Product Name	Carbamic Acid, [(2R,3S)-2-Methyl-4-Oxo-3-Oxetanyl]-, 1,1-Dimethylethyl Ester
CAS No.	710354-67-9
Molecular Formula	C10H15NO4
Molecular Weight	213.23 g/mol
Synonyms	(3S,4R)-3-[(tert-Butoxycarbonyl)amino]-4-methyloxetan-2-one; tert-Butyl N-[(3S,4R)-4-methyl-2-oxo-1,3-oxetanyl]carbamate; Boc-Amino Oxetane-2-one Derivative; (2R,3S)-2-Methyl-4-oxo-3-oxetanylcarbamic Acid tert-Butyl Ester; (3S,4R)-3-(Boc-amino)-4-methyloxetan-2-one; Boc-Protected Oxetanone Amino Acid; Oxetane-2-one, 3-[(tert-butoxycarbonyl)amino]-4-methyl-, (3S,4R)-
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(2R,3S)-2-Methyl-4-Oxo-3-Oxetanyl]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or with appropriate desiccant to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% e.e.
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.