Description

8-(2,2,2-Trifluoroethyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane (Wxfc0424) is a high-value, fluorinated spirocyclic building block essential for advanced organic synthesis. This compound is specifically engineered to introduce the trifluoroethylamine moiety into complex molecular architectures, offering significant advantages in modulating the physicochemical and metabolic properties of target molecules. It is a critical intermediate for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients with enhanced potency and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research where the trifluoroethyl group can improve blood-brain barrier penetration and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms contribute to increased biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty chemicals with unique surface properties and chemical resistance.
• Medicinal Chemistry Scaffold: The spirocyclic structure provides a three-dimensional, rigid framework valuable for exploring novel chemical space in fragment-based drug discovery.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects requiring the incorporation of a protected, fluorinated amine functionality.

Basic Information

Product Name	8-(2,2,2-Trifluoroethyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane (Wxfc0424)
CAS No.	710350-66-6
Molecular Formula	C9H14F3NO2
Molecular Weight	225.21 g/mol
Synonyms	1,4-Dioxa-8-azaspiro[4.5]decane, 8-(2,2,2-trifluoroethyl)-; 8-(2,2,2-Trifluoroethyl)-1,4-dioxa-8-azaspiro[4.5]decane; 8-Trifluoroethyl-1,4-dioxa-8-azaspiro[4.5]decane; N-(2,2,2-Trifluoroethyl)-4-oxopiperidine ethylene ketal; 4,4-Ethylenedioxy-1-(2,2,2-trifluoroethyl)piperidine; Trifluoroethylamino spiroketal; WXFC0424; FC0424.
EINECS	Contact for details

Quality Control

Our 8-(2,2,2-Trifluoroethyl)-1,4-Dioxa-8-Azaspiro[4.5]Decane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider using an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.