Description

6-Oxabicyclo[3.1.0]Hexane-2-Carbonitrile,2-[(Trimethylsilyl)Oxy]-,(1R,2R,5S)-Rel-(9Ci) is a high-value, stereochemically defined bicyclic building block used in advanced organic synthesis. Its unique oxabicyclo[3.1.0]hexane scaffold, combined with the protected cyanohydrin functionality, makes it a critical intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and CNS-targeted drug discovery programs.
• Agrochemical Synthesis: Used as a building block for creating advanced, stereoselective pesticides and herbicides with improved efficacy and environmental profiles.
• Chiral Ligand & Catalyst Development: Serves as a precursor for synthesizing sophisticated chiral auxiliaries, ligands for asymmetric catalysis, and organocatalysts.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with unique thermal or mechanical properties derived from its strained ring system.
• Process Chemistry & Scale-Up: A valuable intermediate for optimizing synthetic routes from laboratory to pilot and commercial scale production in fine chemical manufacturing.

Basic Information

Product Name	6-Oxabicyclo[3.1.0]Hexane-2-Carbonitrile,2-[(Trimethylsilyl)Oxy]-,(1R,2R,5S)-Rel-(9Ci)
CAS No.	709674-10-2
Molecular Formula	C9H15NO2Si
Molecular Weight	197.31 g/mol
Synonyms	(1R,2R,5S)-rel-2-[(Trimethylsilyl)oxy]-6-oxabicyclo[3.1.0]hexane-2-carbonitrile; (1R,2R,5S)-rel-2-(Trimethylsiloxy)-6-oxabicyclo[3.1.0]hexane-2-carbonitrile; 6-Oxabicyclo[3.1.0]hexane-2-carbonitrile, 2-[(trimethylsilyl)oxy]-, (1R,2R,5S)-rel-; TMS-protected cyanohydrin of 6-oxabicyclo[3.1.0]hexan-2-one; Chiral oxabicyclohexane nitrile silyl ether; Bicyclic cyanohydrin TMS ether.
EINECS	Contact for details

Quality Control

Our production of 6-Oxabicyclo[3.1.0]Hexane-2-Carbonitrile,2-[(Trimethylsilyl)Oxy]-,(1R,2R,5S)-Rel-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate to maximize shelf life. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.