Description

(3Rs)-tert-Butyl 1-(5-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate CAS NO 709029-89-0 is a high-purity, chiral pyrrolidine-based building block featuring a protected amine and a free aminopyridine moiety. This compound is a critical intermediate in the synthesis of complex, biologically active molecules, offering precise stereochemical control for advanced pharmaceutical research. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of new drug candidates, particularly in areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a core building block for potential inhibitors targeting various protease enzymes.
• Kinase Inhibitor Development: Employed in the construction of heterocyclic cores for kinase-targeted therapeutic agents.
• Chemical Biology: Utilized as a molecular probe or linker in the study of biological pathways and target engagement.
• Process Chemistry: Investigated for scalable routes in the commercial manufacturing of chiral pharmaceuticals.

Basic Information

Product Name	(3Rs)-tert-Butyl 1-(5-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate
CAS No.	709029-89-0
Molecular Formula	C14H22N4O2
Molecular Weight	278.35 g/mol
Synonyms	tert-Butyl N-[(3R)-1-(5-Amino-2-pyridinyl)-3-pyrrolidinyl]carbamate; (R)-tert-Butyl 1-(5-aminopyridin-2-yl)pyrrolidin-3-ylcarbamate; 1-(5-Aminopyridin-2-yl)-N-Boc-pyrrolidin-3-amine; (R)-1-(5-Aminopyridin-2-yl)pyrrolidin-3-yl-carbamic acid tert-butyl ester; tert-Butyl ((3R)-1-(5-aminopyridin-2-yl)pyrrolidin-3-yl)carbamate; BOC-Protected 5-Amino-2-(3-aminopyrrolidin-1-yl)pyridine; 709029-89-0
EINECS	Contact for details

Quality Control

Our (3Rs)-tert-Butyl 1-(5-Aminopyridin-2-Yl)Pyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.