Description

1R(3R,4S)-4-(tert-Butyldimethylsilyloxy)-3-((tert-Butyldimethylsilyloxy)Methyl)-2-Methylenecyclopentanol is a high-purity, advanced pharmaceutical intermediate featuring a protected cyclopentanol core structure. This compound is critical for the synthesis of complex bioactive molecules, particularly in antiviral and anticancer research, due to its stereochemically defined framework and orthogonal protecting groups. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing novel therapeutic agents.

Application

• Key Intermediate in Nucleoside Analogue Synthesis: Serves as a crucial building block for the development of modified nucleosides with potential antiviral or anticancer activity.
• Chiral Pool for Complex Molecule Construction: Provides a stereochemically rich scaffold for the asymmetric synthesis of complex natural products and drug candidates.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs targeting various diseases.
• Synthesis of Carbocyclic Analogues: Employed in the preparation of carbocyclic nucleosides, which are metabolically more stable than their ribose counterparts.
• Protecting Group Strategy: The tert-butyldimethylsilyl (TBDMS) groups allow for selective deprotection and further functionalization in multi-step syntheses.

Basic Information

Product Name	1R(3R,4S)-4-(tert-Butyldimethylsilyloxy)-3-((tert-Butyldimethylsilyloxy)Methyl)-2-Methylenecyclopentanol
CAS No.	701278-56-0
Molecular Formula	C20H42O3Si2
Molecular Weight	386.73 g/mol
Synonyms	(1R,3R,4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-methylidenecyclopentanol; (1R,3R,4S)-4-((tert-Butyldimethylsilyl)oxy)-3-((tert-butyldimethylsilyloxy)methyl)-2-methylidenecyclopentanol; 2-Methylenecyclopentanol Derivative (TBDMS Protected); Bis-TBDMS Protected Methylenecyclopentanol Intermediate; CAS 701278-56-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Quality assurance is guided by ICH guidelines and we operate under a cGMP-compliant quality management system suitable for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.