Description

3-Chloro-2-(Trimethylsilyl)Pyridine is a versatile organosilicon building block that combines a halogenated pyridine core with a reactive silyl protecting group. This compound matters for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material industries.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of novel heterocyclic compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides that require functionalized pyridine scaffolds.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in cross-coupling and other catalytic reactions.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and other functional materials where silicon-containing pyridines are advantageous.
• Cross-Coupling Reactions: The chloro and trimethylsilyl groups make it a valuable substrate for sequential functionalization via Suzuki, Stille, or other metal-catalyzed couplings.
• Protecting Group Strategy: The trimethylsilyl moiety can act as a temporary protecting group for the 2-position of the pyridine ring in multi-step synthetic sequences.

Basic Information

Product Name	3-Chloro-2-(Trimethylsilyl)Pyridine
CAS No.	79698-47-8
Molecular Formula	C8H12ClNSi
Molecular Weight	185.72 g/mol
Synonyms	2-(Trimethylsilyl)-3-chloropyridine; 3-Chloro-2-pyridinyltrimethylsilane; 3-Chloro-2-trimethylsilylpyridine; Pyridine, 3-chloro-2-(trimethylsilyl)-; 3-Chloro-2-(TMS)pyridine; 3-Chloro-2-(trimethylsilyl)pyridine; 3-Chloro-2-(trimethylsilyl)pyridine (TMS-protected 3-chloropyridine)
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-(Trimethylsilyl)Pyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.