Description

Methyl n-Succinimidoxyacetate CAS NO 79403-55-7 is a specialized organic compound featuring a succinimidyl ester group, making it a valuable reagent for bioconjugation and peptide synthesis. Its primary value lies in its reactivity as an amine-reactive crosslinker, enabling the stable modification of proteins, antibodies, and other biomolecules under mild aqueous conditions. This product is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity intermediates for developing targeted therapeutics, immunoassays, and advanced research tools.

Application

• Bioconjugation Reagent: Used for the covalent attachment of peptides, proteins, or fluorescent dyes to antibodies, enzymes, or nanoparticles.
• Peptide Synthesis Intermediate: Serves as a building block in solid-phase peptide synthesis (SPPS) for introducing specific functional handles.
• ADC (Antibody-Drug Conjugate) Development: A key chemical linker precursor for connecting cytotoxic payloads to monoclonal antibodies in targeted cancer therapy research.
• Surface Functionalization: Employed to modify the surface of biosensors, microarrays, and chromatographic media with amine-reactive groups.
• Polymer Chemistry: Acts as a monomer or crosslinking agent for creating functional polymers with bioactive properties.
• Diagnostic Kit Manufacturing: Utilized in the production of enzyme-linked immunosorbent assay (ELISA) kits and other diagnostic reagents.

Basic Information

Product Name	Methyl n-Succinimidoxyacetate
CAS No.	79403-55-7
Molecular Formula	C7H9NO5
Molecular Weight	187.15 g/mol
Synonyms	Methyl (succinimidyloxy)acetate; N-Hydroxysuccinimide methyl acetate; Succinimidyloxyacetic acid methyl ester; Methyl N-succinimidyloxyacetate; Methyl 2,5-dioxopyrrolidin-1-yl acetate; Methyl 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetate; Methyl N-(succinimidyloxy)acetate; Methyl glycolate N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Methyl n-Succinimidoxyacetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications. Each lot undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.