Description

Monacolin L is a bioactive secondary metabolite, a statin-related compound primarily known for its role as a biosynthetic precursor to Monacolin K (Lovastatin). This high-purity intermediate is critical for ensuring the quality and efficacy of downstream pharmaceutical and nutraceutical products. It is essential for manufacturers in the pharmaceutical, dietary supplement, and advanced biochemical research sectors who require a reliable and consistent supply of key statin precursors.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of cholesterol-lowering agents like Monacolin K (Lovastatin).
• Nutraceutical Production: Used in the manufacture of high-quality red yeast rice extracts and dietary supplements targeting cardiovascular health.
• Biochemical Research: Serves as a critical standard and reference material in metabolic pathway studies and HMG-CoA reductase inhibition research.
• Quality Control Standard: Employed as an analytical reference standard for HPLC and LC-MS methods to assay Monacolin content in raw materials and finished products.
• Fermentation Process Optimization: Used in R&D to study and enhance the yield of monacolin compounds in microbial fermentation processes.

Basic Information

Product Name	Monacolin L
CAS No.	79394-47-1
Molecular Formula	C24H36O5
Molecular Weight	404.54 g/mol
Synonyms	Monacolin L; Dihydromonacolin L; (4R,6R)-6-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-6-hydroxy-8-[(2S)-2-methylbutyryloxy]-2-methyl-1-naphthalenyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one; Lovastatin related compound L; 6α-Hydroxymonacolin L
EINECS	Contact for details

Quality Control

Our Monacolin L is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for pharmaceutical and nutraceutical use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.