Description

Triethylsilyl Trifluoromethanesulfonate is a highly reactive organosilicon reagent, specifically a silyl triflate. Its primary value lies in its exceptional efficacy as a powerful silylating agent and Lewis acid catalyst in complex organic synthesis. This compound is indispensable for researchers and process chemists in the pharmaceutical and fine chemical industries, where it is used to introduce the triethylsilyl protecting group and to facilitate challenging bond-forming reactions under mild conditions.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the protection of hydroxyl groups in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Catalyst in Organic Transformations: Acts as a potent Lewis acid catalyst to promote Friedel-Crafts alkylations, acylations, and other electrophilic aromatic substitution reactions.
• Polymer Chemistry: Used as an initiator or catalyst in the polymerization of specific monomers and in the modification of polymer side chains.
• Silyl Enol Ether Formation: Crucial for the generation of silyl enol ethers from ketones, which are versatile intermediates for regioselective alkylation and aldol reactions.
• Material Science Research: Employed in surface functionalization and the synthesis of advanced silicon-containing materials and precursors.
• Glycosylation Reactions: Facilitates the synthesis of complex oligosaccharides and glycoconjugates by activating glycosyl donors.

Basic Information

Product Name	Triethylsilyl Trifluoromethanesulfonate
CAS No.	79271-56-0
Molecular Formula	C7H15F3O3SSi
Molecular Weight	264.34 g/mol
Synonyms	Triethylsilyl Triflate; TES Triflate; Triethylsilyl Trifluoromethanesulphonate; Triethylsilyl Trifluoromethylsulfonate; (Triethylsilyl) Trifluoromethanesulfonate; Trifluoromethanesulfonic Acid Triethylsilyl Ester; TESOTf; EINECS 279-358-9
EINECS	279-358-9

Quality Control

Every batch of Triethylsilyl Trifluoromethanesulfonate is manufactured and tested under strict quality management systems. We ensure high purity and consistency through advanced analytical techniques including NMR, GC, and HPLC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee it meets the stringent requirements for research and process-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.