Description

2-(Trimethylsilyl)Thiazole is a versatile organosilicon reagent featuring a thiazole ring protected by a trimethylsilyl (TMS) group. This compound is a valuable synthetic intermediate, prized for its role in facilitating challenging coupling reactions and serving as a masked precursor for thiazole derivatives. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing thiazole or modified heterocyclic cores.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides where the thiazole moiety imparts biological activity.
• Cross-Coupling Reactions: Serves as a stable organometallic reagent in palladium-catalyzed cross-couplings, such as Suzuki or Stille reactions, for carbon-carbon bond formation.
• Material Science Research: Employed in the development of organic semiconductors, ligands for catalysis, and other functional organic materials.
• Nucleoside & Nucleotide Chemistry: Acts as a protecting group or intermediate in the modification of nucleosides for medicinal chemistry applications.
• Chemical Derivatization: Useful for introducing the thiazole functionality into larger molecular architectures under mild conditions.

Basic Information

Product Name	2-(Trimethylsilyl)Thiazole
CAS No.	79265-30-8
Molecular Formula	C6H11NSSi
Molecular Weight	157.31 g/mol
Synonyms	2-Trimethylsilylthiazole; Thiazole, 2-(trimethylsilyl)-; 2-TMS-thiazole; Trimethyl(2-thiazolyl)silane; 2-Thiazolyltrimethylsilane; 2-(Trimethylsilyl)-1,3-thiazole
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Thiazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.