Description

2-Methyl-n-[(Trimethylsilyl)Methyl]-2-Propanamine is a specialized organosilicon amine compound featuring a reactive primary amine group protected by a bulky tert-butyl and a trimethylsilylmethyl moiety. This unique structure makes it a valuable synthetic intermediate and protecting group reagent in advanced organic synthesis. It is primarily used by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science sectors for constructing complex molecules and modifying surfaces.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing sterically hindered amine functionalities.
• Ligand Synthesis: Used in the preparation of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Surface Modification Agent: Employed to functionalize silica, glass, or other oxide surfaces via its reactive amine group, altering surface properties for specific applications.
• Agrochemical Synthesis: Acts as an intermediate in the production of specialized herbicides, fungicides, and plant growth regulators.
• Polymer Chemistry: Utilized as a monomer or chain modifier in the synthesis of specialty polyamides, polyurethanes, and silicone-based polymers.
• Protecting Group Strategy: The trimethylsilylmethyl group can act as a protective group for amines in multi-step synthetic sequences.

Basic Information

Item	Details
Product Name	2-Methyl-n-[(Trimethylsilyl)Methyl]-2-Propanamine
CAS No.	79250-80-9
Molecular Formula	C8H21NSi
Molecular Weight	159.35 g/mol
Synonyms	1-(Trimethylsilyl)-2-methyl-2-propanamine; (Trimethylsilyl)methyl-tert-butylamine; N-[(Trimethylsilyl)methyl]-2-methyl-2-propanamine; 2-Methyl-2-[(trimethylsilyl)methyl]aminopropane; tert-Butyl(trimethylsilylmethyl)amine; t-Butyl(trimethylsilylmethyl)amine; TBSM-t-butylamine
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-n-[(Trimethylsilyl)Methyl]-2-Propanamine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Every lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.