Description

4-[(2R,3S,4R,5R)-5-(1,3-Benzodioxol-5-Yl)Tetrahydro-3,4-Dimethyl-2-Furanyl]-2-Methoxyphenol is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key chiral building block in the development of complex, biologically active molecules, offering precise control over molecular architecture. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, agrochemicals, and fine chemicals where specific stereochemistry is critical for function.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral precursor in the synthesis of potential active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-inflammatory targets.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides where the defined spatial orientation enhances biological activity and selectivity.
• Academic & R&D Laboratories: Employed as a model compound or starting material for methodological studies in asymmetric synthesis and natural product analog development.
• Fine Chemical Synthesis: Acts as a specialized building block for creating complex fragrance molecules, flavors, or advanced material precursors requiring specific stereocenters.
• Process Chemistry Development: Utilized in scaling up synthetic routes for candidate drugs, where a reliable supply of high-purity, stereochemically pure intermediates is essential.

Basic Information

Product Name	4-[(2R,3S,4R,5R)-5-(1,3-Benzodioxol-5-Yl)Tetrahydro-3,4-Dimethyl-2-Furanyl]-2-Methoxyphenol
CAS No.	78919-28-5
Molecular Formula	C20H22O5
Molecular Weight	342.39 g/mol
Synonyms	2-Methoxy-4-[(2R,3S,4R,5R)-5-(1,3-benzodioxol-5-yl)tetrahydro-3,4-dimethyl-2-furanyl]phenol; (2R,3S,4R,5R)-5-(1,3-Benzodioxol-5-yl)-3,4-dimethyltetrahydrofuran-2-yl)-2-methoxyphenol; 4-[(2R,3S,4R,5R)-5-(1,3-Benzodioxol-5-yl)-3,4-dimethyltetrahydrofuran-2-yl]-2-methoxyphenol; Stereoisomer of sesamin derivative; Chiral benzodioxole-furan phenol.
EINECS	Contact for details

Quality Control

Our 4-[(2R,3S,4R,5R)-5-(1,3-Benzodioxol-5-Yl)Tetrahydro-3,4-Dimethyl-2-Furanyl]-2-Methoxyphenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.