Description

4-Azido-2-Nitrobenzoylthiamine is a specialized thiamine (vitamin B1) derivative, distinguished by its azido and nitrobenzoyl functional groups. This compound is of significant interest in biochemical research and pharmaceutical development due to its potential as a photoaffinity labeling agent or a precursor for targeted drug delivery systems. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced studies of thiamine metabolism, enzyme inhibition, and the synthesis of novel bioactive molecules.

Application

• Photoaffinity Labeling: Acts as a critical reagent in photochemical cross-linking studies to investigate protein-ligand interactions and enzyme active sites.
• Biochemical Research: Serves as a key intermediate in the synthesis of modified thiamine analogs for studying metabolic pathways and cofactor functions.
• Pharmaceutical Development: Used as a building block in the research and development of novel prodrugs or targeted therapeutic agents.
• Enzyme Inhibition Studies: Employed to design and synthesize potential inhibitors for thiamine-dependent enzymes.
• Chemical Biology Probes: Facilitates the creation of molecular probes for labeling and tracking biological processes in vitro.

Basic Information

Product Name	4-Azido-2-Nitrobenzoylthiamine
CAS No.	78897-57-1
Molecular Formula	C19H17N7O4S
Molecular Weight	439.45 g/mol
Synonyms	Thiamine 4-azido-2-nitrobenzoate; Vitamin B1 4-azido-2-nitrobenzoic acid ester; 4-Azido-2-nitrobenzoic acid thiamine ester; 4-Azido-2-nitrobenzoyl thiamine; ANB-thiamine; 2-[(4-Azido-2-nitrobenzoyl)oxy]ethyl-3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium
EINECS	Contact for details

Quality Control

Our 4-Azido-2-Nitrobenzoylthiamine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR) for structural confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.