Description

1-Iodo-3-[(tert-Butyldimethylsilyl)Oxy]Propane is a versatile organosilicon-protected iodoalkane building block, essential for advanced organic synthesis. Its primary value lies in its dual functionality, where the iodo group serves as an excellent electrophile for cross-coupling reactions, while the TBDMS-protected alcohol provides a stable handle for subsequent deprotection and functionalization. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures, particularly in nucleoside and carbohydrate chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Serves as an electrophilic partner in Negishi, Stille, and Suzuki-Miyaura cross-coupling reactions to form carbon-carbon bonds.
• Alkylation Agent: Used for the selective alkylation of nucleophiles such as enolates, amines, and thiols in multi-step synthetic sequences.
• Polymer & Materials Science: Monomer or functionalization agent in the development of specialty polymers and functionalized surfaces.
• Carbohydrate & Glycochemistry: Employed in the synthesis of complex glycosides and modified sugars where temporary hydroxyl protection is required.
• Agrochemical Synthesis: Intermediate in the production of novel herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Precursor for synthesizing specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Used to create tagged or modified biomolecules for research and diagnostic applications.

Basic Information

Product Name	1-Iodo-3-[(tert-Butyldimethylsilyl)Oxy]Propane
CAS No.	78878-05-4
Molecular Formula	C9H21IOSi
Molecular Weight	300.26 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]-1-iodopropane; 1-Iodo-3-(tert-butyldimethylsilyloxy)propane; 3-Iodopropyl tert-butyldimethylsilyl ether; TBDMS-Protected 3-Iodopropanol; tert-Butyl((3-iodopropoxy)dimethyl)silane; (3-Iodopropoxy)(tert-butyl)dimethylsilane; 3-(tert-Butyldimethylsiloxy)-1-iodopropane
EINECS	Contact for details

Quality Control

Our 1-Iodo-3-[(tert-Butyldimethylsilyl)Oxy]Propane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and iodometric titration, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Iodine Content (Titration)	Conforms to theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.