Description

n-(tert-Butoxycarbonyl)-2-Bromoaniline is a protected aniline derivative, a crucial building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine group, allowing for selective reactions on other functional sites within complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, particularly those containing substituted aniline moieties.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the bromo and protected amine functionalities are essential for activity.
• Peptide Mimetics & Conjugation: Serves as a protected amine component for creating non-natural amino acids or for conjugation strategies in bioconjugation chemistry.
• Material Science Research: Employed in the synthesis of organic semiconductors, ligands for catalysts, and specialty polymers.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Heck, or Buchwald-Hartwig amination after deprotection.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-2-Bromoaniline
CAS No.	78839-75-5
Molecular Formula	C11H14BrNO2
Molecular Weight	272.14 g/mol
Synonyms	2-Bromo-N-(tert-butoxycarbonyl)aniline; 2-Bromoaniline, N-BOC protected; N-Boc-2-bromoaniline; tert-Butyl (2-bromophenyl)carbamate; (2-Bromophenyl)carbamic acid tert-butyl ester; BOC-2-Bromoaniline; N-(tert-Butoxycarbonyl)-2-bromobenzenamine; N-Boc-o-bromoaniline
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-2-Bromoaniline is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.