Description

(E)-2-Methyl-2-Butenoic Acid [(6R,7R,9S,10E,11Ar)-9-Acetoxy-3-Acetoxymethyl-2,4,5,6,7,8,9,11A-Octahydro-6,10-Dimethyl-2-Oxo-6,9-Epoxycyclodeca[B]Furan-7-Yl] Ester is a complex, high-purity synthetic intermediate with a defined stereochemistry, crucial for advanced pharmaceutical research and development. This compound serves as a key chiral building block in the synthesis of intricate natural product analogs and novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in complex, multi-step organic synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex macrocyclic and polycyclic drug candidates, particularly in oncology and anti-infective research.
• Chiral Building Block: Used in asymmetric synthesis to construct molecules with specific three-dimensional configurations essential for biological activity.
• Natural Product Synthesis: Employed in the laboratory-scale total synthesis or semi-synthesis of complex natural products and their derivatives for biological evaluation.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to develop new chemical entities with optimized properties.
• Process Chemistry Development: Used in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific ester moiety.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in related synthetic pathways.

Basic Information

Item	Details
Product Name	(E)-2-Methyl-2-Butenoic Acid [(6R,7R,9S,10E,11Ar)-9-Acetoxy-3-Acetoxymethyl-2,4,5,6,7,8,9,11A-Octahydro-6,10-Dimethyl-2-Oxo-6,9-Epoxycyclodeca[B]Furan-7-Yl] Ester
CAS No.	78835-07-1
Molecular Formula	C24H32O9
Molecular Weight	464.51 g/mol
Synonyms	2-Methyl-2-butenoic acid (6R,7R,9S,10E,11aR)-9-(acetyloxy)-3-(acetyloxymethyl)-2,4,5,6,7,8,9,11a-octahydro-6,10-dimethyl-2-oxo-6,9-epoxycyclodeca[b]furan-7-yl ester; Tiglic acid ester of a modified furanosteroid derivative; (E)-2-Methylcrotonic acid ester; 78835-07-1; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (E)-2-Methyl-2-Butenoic Acid Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm stereochemical integrity, ensuring it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic profiles (NMR, MS) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.