Description

Sarmazenil CAS NO 78771-13-8 is a selective benzodiazepine receptor antagonist, a compound of significant interest in advanced pharmaceutical research and development. Its primary value lies in its ability to reverse the effects of benzodiazepines, making it a critical tool for studying neurological pathways and developing therapeutic countermeasures. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on neuroscience, anesthesia, and toxicology.

Application

• Pharmaceutical Research: Used as a reference standard and active agent in studies of benzodiazepine pharmacology and receptor binding.
• Neuroscience Studies: A key tool for investigating GABAA receptor function and the mechanisms of sedation and anesthesia reversal.
• Toxicology & Antidote Development: Serves as a potential antidote in research models for benzodiazepine overdose.
• Preclinical & Clinical Development: Employed in the development and testing of new therapeutic agents targeting the central nervous system.
• Analytical Standard: Used as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Chemical Synthesis: Acts as a specialized intermediate or building block in the synthesis of novel pharmaceutical compounds.

Basic Information

Product Name	Sarmazenil
CAS No.	78771-13-8
Molecular Formula	C15H12FN3O2
Molecular Weight	285.27 g/mol
Synonyms	Sarmazenil; Ro 15-3505; Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester; Ro 15-3505; Ro15-3505; Ro 153505
EINECS	Contact for details

Quality Control

Our Sarmazenil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and stringent control of residual solvents and impurities. We provide Certificates of Analysis (COA) with detailed results for traceability and compliance. Our quality commitment ensures the material meets the high standards required for pharmaceutical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.