Description

Flumazenil is a selective benzodiazepine receptor antagonist, a high-purity pharmaceutical active ingredient essential for reversing the sedative effects of benzodiazepines. Its primary value lies in providing a critical safety mechanism in clinical and emergency medicine, allowing for the controlled management of benzodiazepine-induced sedation. This compound is vital for manufacturers of injectable pharmaceuticals, hospital pharmacies, and clinical research organizations focused on anesthesia and toxicology.

Application

• Pharmaceutical Manufacturing: As the active pharmaceutical ingredient (API) in injectable formulations for the reversal of benzodiazepine sedation and overdose.
• Hospital & Clinical Use: For the management of postoperative sedation and the treatment of benzodiazepine overdose in emergency and intensive care settings.
• Diagnostic Aid: Used in medical procedures to differentiate between psychiatric and neurological conditions when benzodiazepine use is suspected.
• Research & Development: A key reference standard and tool compound in neuroscience and pharmacology research studying GABAA receptor function.
• Veterinary Medicine: Applied in veterinary clinics for reversing sedation in animals following benzodiazepine administration.

Basic Information

Product Name	Flumazenil
CAS No.	78755-81-4
Molecular Formula	C15H14FN3O3
Molecular Weight	303.29 g/mol
Synonyms	Flumazenil; Ro 15-1788; Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; Anexate; Lanexat; Romazicon; Flumazepil; Benzodiazepine Antagonist Ro 15-1788
EINECS	Contact for details

Quality Control

Our Flumazenil is manufactured under strict quality management systems, targeting specifications suitable for pharmaceutical applications. Quality is assured through comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.