Description

1,2-o-Isopropylidene-α-D-Glucofuranosiduronoic Acid 5-o-Pivaloate 6,3-Lactone is a high-purity, protected carbohydrate derivative that serves as a critical chiral building block and synthetic intermediate. This compound is valued for its role in the stereoselective synthesis of complex molecules, enabling precise chemical transformations. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, nucleoside analogs, and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of nucleoside-based antiviral and anticancer drugs.
• Glycochemistry Research: Used in the synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics for biological studies.
• Chemical Biology Probes: Serves as a precursor for labeled sugars or inhibitors used to study enzymatic pathways and carbohydrate-protein interactions.
• Process Chemistry: Employed in scale-up and route development for the production of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Academic & Industrial R&D: Utilized in laboratories for methodological development in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	1,2-o-Isopropylidene-α-D-Glucofuranosiduronoic Acid 5-o-Pivaloate 6,3-Lactone
CAS No.	78748-89-7
Molecular Formula	C₁₄H₂₀O₇
Molecular Weight	300.30 g/mol
Synonyms	1,2-O-Isopropylidene-α-D-glucofuranosidurono-6,3-lactone 5-pivalate; 1,2:5,6-Di-O-isopropylidene-α-D-glucofuranurono-6,3-lactone (common misnomer); 5-O-Pivaloyl-1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone; Pivaloyl-protected glucofuranuronolactone; Isopropylidene glucofuranuronolactone pivalate; 78748-89-7; α-D-Glucofuranosiduronic acid, 1,2-O-(1-methylethylidene)-, 5-(2,2-dimethylpropanoate) 6,3-lactone
EINECS	Contact for details

Quality Control

Our 1,2-o-Isopropylidene-α-D-Glucofuranosiduronoic Acid 5-o-Pivaloate 6,3-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and optical rotation measurement, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is kept sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-50° to -55° (c=1 in CHCl₃)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.