Description

Tetraethyl Difluoromethylenebisphosphonate is a specialized organophosphorus compound featuring a difluoromethylene bridge, serving as a versatile and critical building block in advanced chemical synthesis. Its unique structure makes it an essential precursor for the development of novel pharmaceuticals, agrochemicals, and functional materials. This high-purity intermediate is particularly valuable for researchers and manufacturers in the fine chemical, life sciences, and material science sectors seeking to incorporate bisphosphonate or fluorine-containing motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of bisphosphonate drugs for treating bone disorders and other therapeutic agents.
• Agrochemical Synthesis: Building block for creating novel herbicides, pesticides, and plant growth regulators with enhanced activity.
• Ligand and Catalyst Development: Used to prepare chelating ligands and organocatalysts for asymmetric synthesis and metal complexation.
• Material Science Research: Monomer or additive for developing flame-retardant polymers, specialty coatings, and advanced functional materials.
• Chemical Biology Probes: Serves as a core structure for designing enzyme inhibitors and molecular probes targeting metabolic pathways.
• Fluorine Chemistry: Valuable synthon for introducing the difluoromethylene (CF2) group into complex organic molecules.

Basic Information

Product Name	Tetraethyl Difluoromethylenebisphosphonate
CAS No.	78715-58-9
Molecular Formula	C9H20F2O6P2
Molecular Weight	324.20 g/mol
Synonyms	Tetraethyl (Difluoromethylene)diphosphonate; (Difluoromethylene)bisphosphonic Acid Tetraethyl Ester; Tetraethyl (Difluoromethylene)bisphosphonate; Difluoromethylenebis(phosphonic Acid Tetraethyl Ester); Tetraethyl Ester of (Difluoromethylene)diphosphonic Acid; 78715-58-9; (CF2)(PO(OEt)2)2
EINECS	Contact for details

Quality Control

Our Tetraethyl Difluoromethylenebisphosphonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
NMR Purity (1H NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.