Description

5-Bromo-2-Chloro-3-Pyridinecarbonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. This compound is valued for its reactive acid chloride group and halogenated pyridine core, enabling precise molecular construction. It is primarily used by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic structure.
• Material Science Research: Serves as a building block for creating functionalized polymers, ligands for metal-organic frameworks (MOFs), and specialty dyes.
• Cross-Coupling Reactions: An effective substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Nucleophilic Substitution: The reactive carbonyl chloride group facilitates amidation and esterification reactions to create amides and esters for further functionalization.

Basic Information

Product Name	5-Bromo-2-Chloro-3-Pyridinecarbonyl Chloride
CAS No.	78686-86-9
Molecular Formula	C6H2BrCl2NO
Molecular Weight	255.90 g/mol
Synonyms	3-Pyridinecarbonyl chloride, 5-bromo-2-chloro-; 5-Bromo-2-chloronicotinoyl chloride; 2-Chloro-5-bromonicotinoyl chloride; 5-Bromo-2-chloropyridine-3-carbonyl chloride; 5-Bromo-2-chloro-3-pyridinecarboxylic acid chloride; 78686-86-9; 5-Br-2-Cl-3-PyCOCl
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-3-Pyridinecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.