Description

3-Pyridinecarbonylchloride,6-Chloro-5-Fluoro-(9Ci) is a high-purity, multi-functional heterocyclic building block essential for advanced synthetic chemistry. Its core value lies in its reactive acid chloride group and halogenated pyridine ring, enabling precise molecular construction in complex organic syntheses. This compound is critically needed by R&D and production chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly in the creation of fluorinated and chlorinated pyridine derivatives.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting central nervous system (CNS) disorders and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the chloro-fluoro-pyridine moiety enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands, metal-organic frameworks (MOFs), and specialty polymers requiring halogenated pyridine units.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for fine chemical manufacturers offering bespoke synthesis services for niche and proprietary compounds.

Basic Information

Product Name	3-Pyridinecarbonylchloride,6-Chloro-5-Fluoro-(9Ci)
CAS No.	78686-85-8
Molecular Formula	C7H2Cl2FNO
Molecular Weight	194.00 g/mol
Synonyms	6-Chloro-5-fluoronicotinoyl chloride; 6-Chloro-5-fluoro-3-pyridinecarbonyl chloride; 6-Chloro-5-fluoropyridine-3-carbonyl chloride; 3-Carbonylchloride-6-chloro-5-fluoropyridine; 5-Fluoro-6-chloronicotinoyl chloride; (6-Chloro-5-fluoropyridin-3-yl)carbonyl chloride; Nicotinoyl chloride, 6-chloro-5-fluoro-
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarbonylchloride,6-Chloro-5-Fluoro-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to cGMP and ISO standards ensures consistent quality and traceability for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.