Description

Methyl 2-Chloro-5-Iodonicotinate is a versatile halogenated nicotinate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a functionalized pyridine scaffold that enables the construction of complex molecules for research and development. This compound is essential for pharmaceutical chemists and agrochemical researchers engaged in the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other small-molecule drugs.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-deficient aromatic system.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic substitutions to introduce diverse functional groups at the iodine and chlorine sites.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	Methyl 2-Chloro-5-Iodonicotinate
CAS No.	78686-83-6
Molecular Formula	C7H5ClINO2
Molecular Weight	297.48 g/mol
Synonyms	2-Chloro-5-iodonicotinic acid methyl ester; Methyl 2-chloro-5-iodopyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-chloro-5-iodo-, methyl ester; 5-Iodo-2-chloronicotinic acid methyl ester; 2-Chloro-5-iodo-3-pyridinecarboxylic acid methyl ester; Methyl 5-iodo-2-chloronicotinate
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Chloro-5-Iodonicotinate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.