Description

6-Bromo-5-Chloro-Nicotinic Acid Methyl Ester is a high-purity, multi-halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromo and chloro substituents.
• Library Synthesis for Drug Discovery: A valuable scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Item	Detail
Product Name	6-Bromo-5-Chloro-Nicotinic Acid Methyl Ester
CAS No.	78686-80-3
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	Methyl 6-Bromo-5-Chloronicotinate; 5-Chloro-6-Bromonicotinic Acid Methyl Ester; 6-Bromo-5-Chloro-3-Pyridinecarboxylic Acid Methyl Ester; Methyl 5-Chloro-6-Bromonicotinate; 3-(Methoxycarbonyl)-5-Chloro-6-Bromopyridine; 6-Bromo-5-Chloro-3-Carbomethoxypyridine; 5-Chloro-6-Bromo-3-Pyridinecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-5-Chloro-Nicotinic Acid Methyl Ester is manufactured under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency through rigorous analytical testing, including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.