Description

6-Chloro-5-Fluoropyridine-3-Carboxylic Acid Methyl Ester is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluoropyridine core contributes to biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and material science applications.
• Chemical Research: Employed in academic and industrial R&D for exploring new heterocyclic chemistry and synthesizing novel fluorinated compounds.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and liquid crystals due to its aromatic, halogenated structure.

Basic Information

Product Name	6-Chloro-5-Fluoropyridine-3-Carboxylic Acid Methyl Ester
CAS No.	78686-78-9
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	Methyl 6-Chloro-5-fluoronicotinate; 5-Fluoro-6-chloropyridine-3-carboxylic acid methyl ester; 3-Pyridinecarboxylic acid, 6-chloro-5-fluoro-, methyl ester; 6-Chloro-5-fluoro-3-pyridinecarboxylic acid methyl ester; Methyl 6-chloro-5-fluoro-3-pyridinecarboxylate; 6-Chloro-5-fluoronicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Fluoropyridine-3-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports your regulatory needs in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is moisture-sensitive; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.