Description

Methyl 5-Bromo-6-Chloropyridine-3-Carboxylate is a high-purity, multi-halogenated pyridine derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its unique substitution pattern, which provides versatile reactivity for constructing complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require halogenated pyridine cores.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the presence of both bromo and chloro leaving groups.
• Nucleophilic Substitution: The electron-deficient pyridine ring and halogen atoms facilitate nucleophilic aromatic substitution, enabling further functionalization.
• Chemical Library Development: A valuable starting material for generating diverse compound libraries in medicinal chemistry for high-throughput screening.

Basic Information

Product Name	Methyl 5-Bromo-6-Chloropyridine-3-Carboxylate
CAS No.	78686-77-8
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	5-Bromo-6-chloropyridine-3-carboxylic acid methyl ester; Methyl 5-bromo-6-chloro-3-pyridinecarboxylate; 3-Pyridinecarboxylic acid, 5-bromo-6-chloro-, methyl ester; 5-Bromo-6-chloro-nicotinic acid methyl ester; 5-Bromo-6-chloro-3-pyridinecarboxylic acid methyl ester; Methyl 5-bromo-6-chloronicotinate
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-6-Chloropyridine-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.