Description

[(4-Methoxyphenyl)Methyl] Hydrogen (4-Hydroxyphenyl)Malonate is a specialized malonate ester derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique bifunctional structure, featuring both methoxy-protected and free phenolic groups, makes it a valuable building block for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors who require high-purity intermediates for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors, and other bioactive molecules with phenolic frameworks.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators that leverage its phenolic and ester functionalities.
• Polymer & Material Science: Monomer or cross-linking agent for producing specialty polyesters, epoxy resins, and high-performance polymers with tailored thermal and mechanical properties.
• Liquid Crystal & OLED Materials: Intermediate in the manufacture of advanced electronic materials, where its rigid, aromatic structure contributes to desired optical and electronic characteristics.
• Fine Chemical & Flavor/Fragrance Synthesis: Used in multi-step syntheses to create complex esters and aromatic compounds for specialty applications.
• Academic & R&D: Serves as a versatile starting material in medicinal chemistry research and process development for new chemical entities.

Basic Information

Product Name	[(4-Methoxyphenyl)Methyl] Hydrogen (4-Hydroxyphenyl)Malonate
CAS No.	78641-40-4
Molecular Formula	C17H16O6
Molecular Weight	316.31 g/mol
Synonyms	(4-Hydroxyphenyl)malonic acid mono(4-methoxybenzyl) ester; Mono(4-methoxybenzyl) (4-hydroxyphenyl)malonate; 4-Methoxybenzyl hydrogen 4-hydroxybenzylidenemalonate; Benzyl (4-hydroxyphenyl)malonate, 4-methoxy- derivative; p-Methoxybenzyl p-hydroxyphenylmalonate; Malonic acid, (4-hydroxyphenyl)-, mono(4-methoxybenzyl) ester
EINECS	Contact for details

Quality Control

Our [(4-Methoxyphenyl)Methyl] Hydrogen (4-Hydroxyphenyl)Malonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) documenting all specifications are available upon request, supporting compliance in GMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.