Description

2H-1,3,2-Oxazaphosphorine, Tetrahydro-2-(Bis(2-Chloroethyl)Amino)-5-Chloro-, 2-Oxide, (Z)- is a specialized organophosphorus compound of significant interest in advanced chemical synthesis. Its value lies in its role as a key intermediate or precursor for the development of novel pharmaceutical agents and biologically active molecules. This product is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on creating new therapeutic compounds, particularly in the areas of oncology and targeted drug delivery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of experimental anticancer agents and other specialized pharmaceuticals.
• Research & Development: Used in academic and industrial labs for investigating new chemical entities (NCEs) and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Acts as a precursor for creating complex organophosphorus ligands and catalysts used in asymmetric synthesis.
• Agrochemical Research: Potential intermediate in the development of novel, high-performance crop protection agents.
• Bioconjugation Chemistry: May be utilized in the design of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted therapies.

Basic Information

Product Name	2H-1,3,2-Oxazaphosphorine, Tetrahydro-2-(Bis(2-Chloroethyl)Amino)-5-Chloro-, 2-Oxide, (Z)-
CAS No.	78542-61-7
Molecular Formula	C7H14Cl3N2O2P
Molecular Weight	295.53 g/mol
Synonyms	(Z)-Tetrahydro-2-[bis(2-chloroethyl)amino]-5-chloro-2H-1,3,2-oxazaphosphorine 2-Oxide; 5-Chloro-cyclophosphamide; NSC-344645; Cyclophosphamide Impurity Z (Isomer); (5Z)-5-Chlorocyclophosphamide; 5-Chloro-cyclophosphamide (Z-isomer); Cyclophosphamide Related Compound Z; 2H-1,3,2-Oxazaphosphorin-2-amine, N,N-bis(2-chloroethyl)tetrahydro-5-chloro-, 2-oxide, (5Z)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and consistency, supporting reliable outcomes in downstream synthesis. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. We support compliance with ICH guidelines for impurities and can tailor specifications to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2°C to 8°C (refrigerated). For short-term or in-use periods, storage at controlled room temperature (15°C to 25°C) is acceptable.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.