Description

trans-5-Fluorocyclophosphamide is a fluorinated derivative of the alkylating agent cyclophosphamide, characterized by its specific stereochemistry. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a more targeted or metabolically stable chemotherapeutic prodrug. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery, metabolite studies, and the synthesis of novel anticancer agents.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for quality control and method development in the production of related chemotherapeutic agents.
• Oncology Research: Used as a key intermediate or active metabolite analog in preclinical studies to investigate mechanisms of action, resistance, and metabolic pathways.
• Prodrug Development: Acts as a building block for the synthesis of novel, targeted prodrugs designed to improve therapeutic index and reduce side effects.
• Metabolite Studies: Essential for comparative pharmacokinetic and pharmacodynamic studies against the parent compound, cyclophosphamide.
• Biochemical Research: Employed in studies exploring DNA alkylation, apoptosis induction, and immune modulation mechanisms.
• Contract Manufacturing: Supplied as a high-purity intermediate for cGMP (Current Good Manufacturing Practice) synthesis of clinical trial materials.

Basic Information

Product Name	trans-5-Fluorocyclophosphamide
CAS No.	78542-60-6
Molecular Formula	C7H15Cl2FN2O2P
Molecular Weight	287.08 g/mol
Synonyms	trans-5-Fluoro-cyclophosphamide; 5-Fluoro-cyclophosphamide (trans-); N,N-Bis(2-chloroethyl)-5-fluoro-1,3,2-oxazaphosphinan-2-amine 2-oxide; 5-Fluoro-cyclophosphamide; Cyclophosphamide, 5-fluoro- (trans-); 2-[Bis(2-chloroethyl)amino]-5-fluoro-1,3,2-oxazaphosphorinane 2-oxide
EINECS	Contact for details

Quality Control

Our trans-5-Fluorocyclophosphamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic (HPLC) and spectroscopic (NMR, MS) methods. We adhere to relevant quality guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.