Description

2-Oxo-4-Trifluoromethyl-2,3-Dihydro-Oxazole-5-Carboxylic Acid Ethyl Ester is a high-value fluorinated heterocyclic building block, essential for introducing the trifluoromethyl-oxazole pharmacophore into complex molecular architectures. Its core value lies in enabling the synthesis of novel compounds with enhanced metabolic stability and bioavailability for pharmaceutical research. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting CNS, anti-inflammatory, or anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for studying biological mechanisms and target engagement.
• Process Chemistry & Scale-Up: Critical for optimizing synthetic routes from laboratory to pilot plant scale for cost-effective production of target molecules.

Basic Information

Product Name	2-Oxo-4-Trifluoromethyl-2,3-Dihydro-Oxazole-5-Carboxylic Acid Ethyl Ester
CAS No.	78492-21-4
Molecular Formula	C7H6F3NO4
Molecular Weight	225.12 g/mol
Synonyms	Ethyl 2-oxo-4-(trifluoromethyl)-2,3-dihydro-1,3-oxazole-5-carboxylate; 4-(Trifluoromethyl)-2,5-dihydro-5-oxo-1,3-oxazole-5-carboxylic Acid Ethyl Ester; 5-Oxazolecarboxylic acid, 2,3-dihydro-2-oxo-4-(trifluoromethyl)-, ethyl ester; 2-Oxo-4-trifluoromethyl-2,3-dihydro-oxazole-5-carboxylic acid ethyl ester; 4-Trifluoromethyl-2-oxo-2,3-dihydrooxazole-5-carboxylic Acid Ethyl Ester; Ethyl 4-trifluoromethyl-2-oxo-2,3-dihydrooxazole-5-carboxylate; 78492-21-4
EINECS	Contact for details

Quality Control

Our 2-Oxo-4-Trifluoromethyl-2,3-Dihydro-Oxazole-5-Carboxylic Acid Ethyl Ester is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming it meets the agreed specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.