Description

Ethyl 8-(Hydroxymethyl)-1,4-Dioxaspiro[4.5]Decane-8-Carboxylate is a high-value, multifunctional spirocyclic building block and chiral synthon. This compound is essential for its role in the stereoselective synthesis of complex organic molecules, offering chemists precise control over molecular architecture. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced material sectors for creating novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of prostaglandins, nucleoside analogs, and other bioactive molecules requiring specific stereochemistry.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the spirocyclic structure contributes to biological activity and environmental stability.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical and Fragrance Intermediate: Employed in the construction of complex, odor-active molecules and other specialty chemicals.
• Academic and Industrial R&D: A valuable tool for methodological development in organic synthesis and for exploring new chemical spaces in discovery chemistry.
• Material Science: Potential monomer or cross-linking agent for creating polymers with unique thermal or mechanical properties derived from its rigid spiro structure.

Basic Information

Product Name	Ethyl 8-(Hydroxymethyl)-1,4-Dioxaspiro[4.5]Decane-8-Carboxylate
CAS No.	78461-64-0
Molecular Formula	C12H20O5
Molecular Weight	244.28 g/mol
Synonyms	8-(Hydroxymethyl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester; Ethyl 8-hydroxymethyl-1,4-dioxaspiro[4.5]decane-8-carboxylate; 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(hydroxymethyl)-, ethyl ester; 8-Carbethoxy-8-hydroxymethyl-1,4-dioxaspiro[4.5]decane; Ethyl (8-Hydroxymethyl)-1,4-dioxaspiro[4.5]decane-8-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 8-(Hydroxymethyl)-1,4-Dioxaspiro[4.5]Decane-8-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (Typical)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.