Description

(R)-2-Amino-4-Pentynoic Acid, Methyl Ester is a chiral, non-proteinogenic amino acid derivative featuring a reactive terminal alkyne group. This compound matters as a versatile and high-value building block for the synthesis of complex molecules, enabling the introduction of both a chiral amine and a "click chemistry"-ready handle. It is primarily needed by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing novel therapeutics, diagnostics, and chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and neurology.
• Peptidomimetics & Conjugate Synthesis: Used to incorporate unnatural amino acid residues into peptide chains or to create drug-linker conjugates for targeted therapies.
• Bioconjugation & Probe Development: The terminal alkyne allows for efficient, site-specific labeling of biomolecules (proteins, antibodies, nucleic acids) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Chemical Biology Research: Serves as a tool compound for studying enzyme mechanisms, metabolic pathways, and protein function through incorporation into biomolecules.
• Ligand & Catalyst Development: Utilized in the preparation of chiral ligands for asymmetric catalysis or as a precursor for metal-chelating agents.
• Material Science: Potential monomer or cross-linker for creating novel polymers with specific functional or chiral properties.

Basic Information

Item	Detail
Product Name	(R)-2-Amino-4-Pentynoic Acid, Methyl Ester
CAS No.	78342-50-4
Molecular Formula	C6H9NO2
Molecular Weight	127.14 g/mol
Synonyms	(R)-2-Amino-4-pentynoic acid methyl ester; Methyl (R)-2-amino-4-pentynoate; (R)-Methyl 2-amino-4-pentynoate; D-2-Amino-4-pentynoic acid methyl ester; (2R)-2-Amino-4-pentynoic acid methyl ester; (R)-2-Amino-pent-4-ynoic acid methyl ester; Methyl (R)-2-aminopent-4-ynoate
EINECS	Contact for details

Quality Control

Our (R)-2-Amino-4-Pentynoic Acid, Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.