Description

tert-Butyl(Dimethyl)Silyl 3-Phenylpropanoate is a specialized organosilicon protecting group reagent used in advanced organic synthesis. This compound is valued for its role in the selective protection of carboxylic acid functionalities, offering enhanced stability under a wide range of reaction conditions compared to other silylating agents. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and fine chemical industries developing complex molecules, including active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Carboxylic Acid Protection in Peptide Synthesis: Used to temporarily protect carboxyl groups during the stepwise construction of peptide chains, preventing unwanted side reactions.
• Intermediate for Pharmaceutical APIs: Serves as a key building block in the multi-step synthesis of complex drug molecules, particularly where selective deprotection is required.
• Fine Chemical and Agrochemical Synthesis: Employed in the production of specialty chemicals and agrochemical intermediates that require robust protecting group strategies.
• Academic and Process Chemistry Research: A valuable reagent for method development and exploring new synthetic pathways in laboratory and scale-up environments.
• Synthesis of Fragrance and Flavor Compounds: Used in the controlled synthesis of ester derivatives that are precursors to specific aroma chemicals.

Basic Information

Product Name	tert-Butyl(Dimethyl)Silyl 3-Phenylpropanoate
CAS No.	78324-01-3
Molecular Formula	C15H24O2Si
Molecular Weight	264.44 g/mol
Synonyms	3-Phenylpropanoic Acid tert-Butyldimethylsilyl Ester; TBDMS 3-Phenylpropionate; tert-Butyldimethylsilyl 3-Phenylpropionate; (3-Phenylpropanoyloxy)(tert-butyl)dimethylsilane; TBDMS Phenylpropanoate; tert-Butyl(dimethyl)silyl Hydrocinnamate; Hydrocinnamic Acid TBDMS Ester; TBDMS-Hydrocinnamate
EINECS	Contact for details

Quality Control

Our tert-Butyl(Dimethyl)Silyl 3-Phenylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions, such as a nitrogen or argon atmosphere, for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.