Description

1-(2-(Trimethylsilyl)Ethoxycarbonyloxy) is a specialized organosilicon protecting group reagent, primarily used for the introduction of the Teoc (2-(trimethylsilyl)ethoxycarbonyl) group. This compound is critical in synthetic organic chemistry, particularly in peptide and oligonucleotide synthesis, where it offers a base-labile alternative to traditional carbamate protecting groups. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and orthogonal protection strategies for amines and other nucleophiles during complex multi-step syntheses.

Application

• Peptide Synthesis: As a Teoc-protecting group reagent for the temporary protection of amino acids, offering clean deprotection under mild fluoride conditions.
• Oligonucleotide Synthesis: Used in the protection of exocyclic amino groups on nucleobases during solid-phase synthesis.
• Pharmaceutical Intermediates: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) requiring orthogonal protection strategies.
• Combinatorial Chemistry: Employed in the preparation of compound libraries where selective deprotection is necessary.
• Agrochemical Research: Used in the synthesis of complex molecules for crop protection agents.
• Material Science: Potential applications in the surface functionalization of silicon-based materials and polymers.

Basic Information

Product Name	1-(2-(Trimethylsilyl)Ethoxycarbonyloxy)
CAS No.	78269-85-9
Molecular Formula	C7H15O3Si
Molecular Weight	175.28 g/mol
Synonyms	Teoc-OSu; 2-(Trimethylsilyl)ethyl Succinimidyl Carbonate; 1-[(2-Trimethylsilyl)ethoxycarbonyloxy]pyrrolidine-2,5-dione; N-Succinimidyl 2-(Trimethylsilyl)ethyl Carbonate; Teoc-ONSu; 2,5-Pyrrolidinedione, 1-[[2-(trimethylsilyl)ethoxy]carbonyl]-; Teoc-O-Succinimide; 2-(Trimethylsilyl)ethyl N-Succinimidyl Carbonate
EINECS	Contact for details

Quality Control

Our 1-(2-(Trimethylsilyl)Ethoxycarbonyloxy) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.