Description

Methyl (4R,5S)-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylate is a high-value chiral building block and protected form of a glyceraldehyde derivative. This compound is critical for its role in asymmetric synthesis, providing a stereochemically defined scaffold for constructing complex molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key starting material for the production of nucleoside analogs, antiviral drugs, and other therapeutics requiring specific stereochemistry.
• Asymmetric Synthesis Building Block: Used in the construction of complex natural products and bioactive molecules where control of absolute configuration is essential.
• Organic Chemistry Research: Employed in academic and industrial R&D for developing new synthetic methodologies and catalytic processes.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, and fragrances that utilize its protected aldehyde functionality.
• Agrochemical Intermediate: Potential use in the synthesis of chiral pesticides and herbicides.

Basic Information

Product Name	Methyl (4R,5S)-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylate
CAS No.	78086-72-3
Molecular Formula	C9H16O4
Molecular Weight	188.22 g/mol
Synonyms	(4R,5S)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic acid methyl ester; Methyl (R)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylate; (R)-(-)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester; (4R-cis)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester; D-Glyceraldehyde Acetonide Methyl Ester; (R)-Glyceraldehyde Acetonide Methyl Ester; (4R,5S)-2,2,5-Trimethyl-[1,3]dioxolane-4-carboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Methyl (4R,5S)-2,2,5-Trimethyl-1,3-Dioxolane-4-Carboxylate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]20/D	-15° to -18° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.