Description

H-D-Glu-Obzl·Hcl CAS NO 78057-85-9 is a protected derivative of D-glutamic acid, specifically the hydrochloride salt of its benzyl ester. This compound is a crucial chiral building block and intermediate in the synthesis of complex peptides and pharmaceutical active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-glutamic acid residues with side-chain protection.
• Biochemical Research: Serves as a standard or reagent in metabolic pathway studies and enzyme-substrate interaction research.
• Proteomics & Diagnostics: Employed in the development of specialized peptides for diagnostic assays and biomarker discovery.
• Fine Chemical Production: Intermediate for synthesizing custom amino acid derivatives and non-natural amino acids for material science.
• Academic & R&D: Essential for medicinal chemistry programs and academic research focused on peptide mimetics and drug design.

Basic Information

Product Name	H-D-Glu-Obzl·Hcl
CAS No.	78057-85-9
Molecular Formula	C12H16ClNO4
Molecular Weight	273.71 g/mol
Synonyms	H-D-Glu(OBzl)-OH·HCl; D-Glutamic acid 5-benzyl ester hydrochloride; (R)-2-Amino-5-(benzyloxy)-5-oxopentanoic acid hydrochloride; D-Glu(OBzl)-OH·HCl; Benzyl D-glutamate hydrochloride; Fmoc-D-Glu(OBzl)-OH·HCl precursor; D-Glutamic acid γ-benzyl ester hydrochloride; Protected D-glutamate hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Glu-Obzl·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.