Description

5-Cyano-2-Trimethylsilyl-Thiophene is a high-value organosilicon intermediate featuring a functionalized thiophene core. This compound is critical for its role in advanced material synthesis and pharmaceutical research, where its unique silyl-protected and cyano-substituted structure enables precise molecular construction. It is primarily sought after by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and organic electronics industries for constructing complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing functionalized thiophene or benzothiophene scaffolds.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides, fungicides, and insecticides that require specific heterocyclic motifs for bioactivity.
• Material Science Precursor: Acts as a monomer or precursor in the development of conjugated polymers and organic semiconductors for applications in OLEDs, OFETs, and solar cells.
• Cross-Coupling Reactions: The trimethylsilyl group acts as a protective and directing agent, making this compound valuable in palladium-catalyzed cross-coupling reactions (e.g., Kumada, Negishi, Stille).
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing complex molecular architectures for various applications.

Basic Information

Product Name	5-Cyano-2-Trimethylsilyl-Thiophene
CAS No.	77998-64-2
Molecular Formula	C8H11NSSi
Molecular Weight	181.33 g/mol
Synonyms	2-Trimethylsilyl-5-cyanothiophene; 5-Cyano-2-(trimethylsilyl)thiophene; Thiophene, 5-cyano-2-(trimethylsilyl)-; 2-TMS-5-cyanothiophene; (5-Cyanothiophen-2-yl)trimethylsilane; Trimethyl(5-cyanothiophen-2-yl)silane
EINECS	Contact for details

Quality Control

Every batch of 5-Cyano-2-Trimethylsilyl-Thiophene is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards. Certificates of Analysis (COA) documenting batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.