Description

1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-(2,2-Dimethylpropyl) Ester is a high-purity, specialized dihydropyridine derivative, serving as a critical advanced intermediate in modern pharmaceutical synthesis. Its value lies in its precise molecular architecture, which is essential for constructing complex active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily required by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries for the development and manufacture of cardiovascular and other specialized medications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of dihydropyridine-class calcium channel blockers and other potent APIs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new drug candidates.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for commercial drug manufacturing.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.
• Fine Chemical Synthesis: Utilized in the preparation of other complex, nitrogen-containing heterocyclic compounds.

Basic Information

Product Name	1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-(2,2-Dimethylpropyl) Ester
CAS No.	77888-06-3
Molecular Formula	C23H28N2O6
Molecular Weight	428.48 g/mol
Synonyms	3-Methyl 5-(2,2-Dimethylpropyl) 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-neopentyl ester; Nimodipine Impurity; Nimodipine Related Compound; DHP Ester Derivative; 1,4-DHP Intermediate; Nitrophenyl DHP Ester
EINECS	Contact for details

Quality Control

Our 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 3-Methyl 5-(2,2-Dimethylpropyl) Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet the requirements of cGMP, ICH guidelines, and relevant pharmacopeial standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.