Description

6β-[(Trimethylsilyl)Oxy]-5α-Cholestan-3-One is a high-purity, steroidal intermediate featuring a strategically protected 6β-hydroxyl group. This compound is critical for researchers and manufacturers requiring precise chemical modifications in the synthesis of complex steroid derivatives and pharmaceutical candidates. It is primarily utilized in advanced organic synthesis, process development, and analytical reference standard preparation within the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based therapeutics and active pharmaceutical ingredients (APIs).
• Process Chemistry & R&D: Used in route scouting and optimization for the production of complex steroidal molecules in laboratory and pilot-scale settings.
• Analytical Reference Standard: Serves as a high-purity standard for method development, validation, and quality control (HPLC, GC-MS) in analytical laboratories.
• Biochemical Research: Employed in studies investigating steroid metabolism, enzyme inhibition, and receptor-ligand interactions.
• Fine Chemical Synthesis: A versatile precursor for the preparation of specialized steroidal compounds used in various chemical and material science applications.

Basic Information

Product Name	6β-[(Trimethylsilyl)Oxy]-5α-Cholestan-3-One
CAS No.	77828-31-0
Molecular Formula	C₃₀H₅₄O₂Si
Molecular Weight	466.85 g/mol
Synonyms	5α-Cholestan-3-one, 6β-[(trimethylsilyl)oxy]-; 6β-(Trimethylsiloxy)-5α-cholestan-3-one; 6β-Hydroxy-5α-cholestan-3-one trimethylsilyl ether; 6β-TMS-5α-cholestan-3-one; (3S,5S,6R,8R,9S,10S,13R,14S,17R)-6-[(Trimethylsilyl)oxy]-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-one
EINECS	Contact for details

Quality Control

Our 6β-[(Trimethylsilyl)Oxy]-5α-Cholestan-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.