Description

6β-[(Trimethylsilyl)Oxy]-5α-Cholest-2-Ene is a high-purity, functionalized steroidal intermediate featuring a trimethylsilyl-protected hydroxyl group. This compound is of significant value in advanced organic synthesis and pharmaceutical research, serving as a versatile building block for the development of novel steroid-based therapeutics and bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for the targeted synthesis of complex steroidal architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new steroid-based drugs, including hormone modulators and anti-inflammatory agents.
• Organic Synthesis Building Block: Used in advanced synthetic routes, such as cross-coupling reactions and functional group transformations, to construct complex molecular frameworks.
• Biochemical Research: Employed in the study of steroid metabolism, receptor binding, and the synthesis of labeled compounds for analytical and diagnostic purposes.
• Fine Chemical Production: Serves as a precursor in the manufacture of high-value specialty chemicals and advanced materials with specific steroidal functionalities.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	6β-[(Trimethylsilyl)Oxy]-5α-Cholest-2-Ene
CAS No.	77828-28-5
Molecular Formula	C₃₀H₅₄OSi
Molecular Weight	458.85 g/mol
Synonyms	5α-Cholest-2-en-6β-ol, trimethylsilyl ether; 6β-(Trimethylsiloxy)-5α-cholest-2-ene; Cholest-2-ene-6β-ol, 5α-, trimethylsilyl ether; 5α-Cholest-2-en-6β-yloxytrimethylsilane; (3β,5α,6β)-6-(Trimethylsilyloxy)cholest-2-ene
EINECS	Contact for details

Quality Control

Our 6β-[(Trimethylsilyl)Oxy]-5α-Cholest-2-Ene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.