Description

Methyl 5-Hexynoate is a versatile alkyne-containing ester building block used in advanced organic synthesis. Its terminal alkyne functionality makes it a critical intermediate for click chemistry, particularly in the formation of 1,2,3-triazoles via copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients, polymers, and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex molecules, including potential active pharmaceutical ingredients (APIs) via click chemistry and other coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that incorporate alkyne motifs.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and functionalized surfaces with tailored properties.
• Bioconjugation & Probe Development: Enables the labeling of biomolecules (proteins, peptides, nucleic acids) for diagnostic assays, imaging probes, and targeted drug delivery systems.
• Organic Synthesis Reagent: A fundamental starting material for Sonogashira coupling, hydroalkynylation, and other metal-catalyzed transformations to construct complex molecular architectures.
• Ligand & Catalyst Development: Used to synthesize novel chelating ligands and organometallic complexes for catalytic applications.

Basic Information

Product Name	Methyl 5-Hexynoate
CAS No.	77758-51-1
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	5-Hexynoic acid, methyl ester; Methyl 5-hexynoate; Methyl hex-5-ynoate; 5-Hexynoic acid methyl ester; Methyl pentyl-1-yn-carboxylate; Methyl ester of 5-hexynoic acid; Hex-5-ynoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Hexynoate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, guaranteeing traceability and compliance with your research or production specifications. Our quality system is designed to meet the stringent demands of fine chemical and pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.428 - 1.432
Density (g/mL, 20°C)	0.93 - 0.97

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.